The sixth season of Supernatural takes place after the events of the previous season, where Sam (Jared Padalecki) and Dean (Jensen Ackles) Winchester are still dealing with the aftermath of the Apocalypse. The season focuses on the brothers' journey to find and prevent the activation of the Nephilim, specifically Cassiel's (Misha Collins) son, Jack. Along the way, they encounter various supernatural creatures, including vampires, werewolves, and demons.