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The series revolves around Frank Gallagher (played by William H. Macy), a single father who is often drunk and neglectful, leaving his six children to fend for themselves. The eldest daughter, Fiona (played by Emmy Rossum), takes on the responsibility of caring for her siblings, Lip (Jeremy Allen White), Ian (Cameron Monaghan), Debbie (Emma Greenwell), Carl (Ethan Cutkosky), and Liam (Christian Isaiah).